GEMINI 1
The purpose of this study is to assess the efficacy of two drug treatments measured by annualized adjudicated relapse rate (ARR) in participants with relapsing forms of MS.
Status
Recruiting
Recruiting
Asian Cohort for Alzheimer’s Disease
The purpose of this study is to investigate the impact of genetic and non-genetic risk factors for Alzheimer’s disease (AD), evaluate differential
effects of sex on AD risk, and predict diagnosis of AD using dementia risk scores derived from genetic and nongenetic risk factors.
Status
Recruiting
PORT Trial
The purpose of this study is to evaluate the feasibility of using repetitive transcranial magnetic stimulation (rTMS) to treat depression.
Status
Recruiting
A Study of TAK-079 in People With Generalized Myasthenia Gravis
The purpose of this study is to test the safety and efficacy of TAK-079, a medicine to help people with generalized myasthenia gravis.
Status
Recruiting
Perimenopause Brain Health
The purpose of this study is to is to examine the effects of 12 weeks of high intensity interval training on the cognitive health of perimenopausal woman.
Status
Recruiting
Magnetic Seizure Therapy for Parkinson’s Disease
The purpose of this study is to test the feasibility of magnetic seizure therapy for treating depression in patients diagnosed with Parkinson's Disease.
Status
Recruiting
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (O'HAND)
The purpose of this study is to evaluate the efficacy and safety of ocrelizumab ( Ocrevus®) compared with placebo in participants with primary progressive multiple sclerosis (PPMS).
Status
Recruiting
A Feasibility Study of Adherence to Light Therapy for Maintenance Treatment of Major Depressive Disorder
The purpose of this study is to explore the use of bright light therapy as maintenance treatment for depression to determine if it is
Status
Recruiting
Less is more: Low concentration topical capsaicin to relieve neuropathic pain in spinal cord injury
The purpose of this study is examine the use of low concentration capsaicin (the active ingredient in chili peppers) cream applied for extended periods of time to help manage neuropathic pain after spinal cord injury.
Status
Recruiting
The Up-LIFT Study of Non-Invasive ARC Therapy for Spinal Cord Injury (Up-LIFT)
The purpose of this study is to evaluate the safety and effectiveness of non-invasive electrical spinal stimulation for restoration of upper extremity function.
Status
Recruiting
Effects of Spinal Cord Injury Exercise Guidelines
The purpose of this study is to determine whether a regular program of exercise, performed in a person's home or in fitness facility, can significantly reduce chronic pain in adults with spinal cord injury.
Status
Recruiting
Co-Investigation of Robotic-Assisted Virtual Care for Older People with Dementia - Phase 1
The purpose of this study is to determine ways to meet the social needs related to loneliness and isolation in seniors with dementia while examing barriers and successes surrounding the use of a robot-assisted, virtual care solution within care settings.
Status
Recruiting
Neuromodulation: Bladder Bowel and Sexual Function in SCI
This project is investigating the immediate and long-term effects of non-invasive transcutaneous spinal cord stimulation (TCSCS) on bladder, bowel, and sexual function in people with SCI.
Status
Recruiting
Motor and Autonomic Concomitant Health Improvements With Neuromodulation and Exoskeleton Training: A RCT in Individuals With SCI (MACHINE)
This project aims to assess the efficacy of activity-based therapy in combination with non-invasive transcutaneous spinal cord stimulation to promote the recovery of motor function, bowel function, bladder function, sexual function and quality of life in individuals with spinal cord injury.
Status
Recruiting
Treating Anxiety in Parkinson's Disease With a Multi-Strain Probiotic (TAP)
The purpose of this study is to evaluate the use of an oral multi-strain probiotic in the treatment of anxiety in individuals with Parkinson's Disease.
Status
Recruiting
PRidopidine's Outcome On Function in Huntington Disease (PROOF- HD)
The purpose of this study is to evaluate the efficacy and safety of the drug pridopidine in patients with early stage manifest Huntington Disease.
Status
Recruiting
Canadian Biomarker Integration Network for Depression (CAN-BIND) - Validation Study
The purpose of this study is to learn about biomarkers (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression.
Status
Recruiting
Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in Intracranial Atherosclerotic Disease
The purpose of the study is to better understand the safety of using combination antithrombotic therapy in patients with high risk transient ischemic attack (TIA) or ischemic stroke secondary to ICAD (intracranial atherosclerotic disease) for prevention of recurrent stroke.
Status
Recruiting
A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205
The purpose of the study is to evaluate the long-term safety and tolerability of aducanumab in participants who had previously participated in aducanumab studies.
Status
Recruiting
Secondary Hyperalgesia Following Prolonged Low-Dosage Capsaicin Application
The purpose of this study is to develop a better understanding of the response of heat desensitized skin, resulting from prolonged low percentage capsaicin application, following an adjacent primary sensitization to the surrounding skin.
Status
Recruiting